Biology:SEPT6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Septin-6 is a protein that in humans is encoded by the SEPT6 gene.[1][2][3]
Function
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.[3]
Clinical significance
One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins.[3]
Interactions
SEPT6 has been shown to interact with SEPT2.[4][5]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (4): 167–74, 199–210. August 1995. doi:10.1093/dnares/2.4.167. PMID 8590280.
- ↑ "Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase". The Journal of Biological Chemistry 275 (14): 10047–56. April 2000. doi:10.1074/jbc.275.14.10047. PMID 10744683.
- ↑ 3.0 3.1 3.2 "Entrez Gene: SEPT6 septin 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23157.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell 13 (10): 3532–45. October 2002. doi:10.1091/mbc.E02-01-0042. PMID 12388755.
Further reading
- "Differential localization of septins in the mouse brain". The Journal of Comparative Neurology 428 (2): 223–39. December 2000. doi:10.1002/1096-9861(20001211)428:2<223::AID-CNE3>3.0.CO;2-M. PMID 11064363.
- "SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24". Cancer Research 62 (2): 333–7. January 2002. PMID 11809673.
- "MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site". Oncogene 21 (30): 4706–14. July 2002. doi:10.1038/sj.onc.1205572. PMID 12096348.
- "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Molecular Biology of the Cell 13 (10): 3532–45. October 2002. doi:10.1091/mbc.E02-01-0042. PMID 12388755.
- "Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments". The Journal of Biological Chemistry 278 (5): 3483–8. January 2003. doi:10.1074/jbc.M209701200. PMID 12446710.
- "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells". NeuroReport 14 (1): 31–7. January 2003. doi:10.1097/00001756-200301200-00006. PMID 12544826.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801.
- "Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro". Doklady Biochemistry and Biophysics 391: 195–7. 2004. doi:10.1023/A:1025149005902. PMID 14531065.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia". Cancer Genetics and Cytogenetics 168 (2): 162–7. July 2006. doi:10.1016/j.cancergencyto.2006.02.020. PMID 16843108.
- "Structural analysis of septin 2, 6, and 7 complexes". The Journal of Biological Chemistry 281 (41): 30697–706. October 2006. doi:10.1074/jbc.M605179200. PMID 16914550.
- "An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication". Journal of Virology 81 (8): 3852–65. April 2007. doi:10.1128/JVI.01311-06. PMID 17229681.
- "Structural insight into filament formation by mammalian septins". Nature 449 (7160): 311–5. September 2007. doi:10.1038/nature06052. PMID 17637674. Bibcode: 2007Natur.449..311S.
- "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7". Cell 130 (5): 837–50. September 2007. doi:10.1016/j.cell.2007.06.053. PMID 17803907.
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