Biology:SH2D1B
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 Generic protein structure example |
SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.[1][2][3]
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM][3]
Interactions
SH2D1B has been shown to interact with SLAMF1.[2]
References
- ↑ "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene 13 (12): 2649–58. Feb 1997. PMID 9000139.
- ↑ 2.0 2.1 "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J 20 (21): 5840–52. Nov 2001. doi:10.1093/emboj/20.21.5840. PMID 11689425.
- ↑ 3.0 3.1 "Entrez Gene: SH2D1B SH2 domain containing 1B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117157.
Further reading
- "X-linked lymphoproliferative disease: a progressive immunodeficiency". Annu. Rev. Immunol. 19: 657–82. 2001. doi:10.1146/annurev.immunol.19.1.657. PMID 11244050.
- "The SLAM family of immune-cell receptors". Curr. Opin. Immunol. 15 (3): 277–85. 2004. doi:10.1016/S0952-7915(03)00041-4. PMID 12787752.
- "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". Eur. J. Immunol. 32 (6): 1640–9. 2002. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells". J. Immunol. 177 (5): 3170–7. 2006. doi:10.4049/jimmunol.177.5.3170. PMID 16920955.
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