Biology:SIPA1
From HandWiki
 Generic protein structure example |
Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.[1][2]
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.[2]
References
- ↑ "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human". Genomics 39 (1): 66–73. Mar 1997. doi:10.1006/geno.1996.4464. PMID 9027487.
- ↑ 2.0 2.1 "Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6494.
Further reading
- Minato N (1997). "[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene]". Hum. Cell 9 (1): 11–6. PMID 9183624.
- "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression". Mol. Cell. Biol. 15 (1): 552–60. 1995. doi:10.1128/mcb.15.1.552. PMID 7799964.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product". J. Biol. Chem. 272 (44): 28081–8. 1997. doi:10.1074/jbc.272.44.28081. PMID 9346962.
- "Genomic organization and cloning of the human homologue of murine Sipa-1". Gene 214 (1–2): 215–21. 1998. doi:10.1016/S0378-1119(98)00212-1. PMID 9651531.
- "Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion". J. Biol. Chem. 274 (26): 18463–9. 1999. doi:10.1074/jbc.274.26.18463. PMID 10373454.
- "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis". J. Biol. Chem. 276 (41): 38173–8. 2001. doi:10.1074/jbc.M103140200. PMID 11461903.
- "SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus". Genes Cells 7 (6): 607–17. 2003. doi:10.1046/j.1365-2443.2002.00546.x. PMID 12059963.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization". Mol. Cell. Biol. 24 (20): 9059–69. 2004. doi:10.1128/MCB.24.20.9059-9069.2004. PMID 15456879.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer". Breast Cancer Res. 8 (2): R16. 2006. doi:10.1186/bcr1389. PMID 16563182.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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