Biology:SKIP
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SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.[1]
Function
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[1] Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51763.
- ↑ "The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system". Pflügers Archiv 462 (6): 871–83. Dec 2011. doi:10.1007/s00424-011-1028-0. PMID 21938401. https://www.zora.uzh.ch/id/eprint/53204/1/Pernot_PflugersArch_2011.pdf.
Further reading
- "The family of inositol and phosphatidylinositol polyphosphate 5-phosphatases". Biochemical Society Transactions 24 (4): 1001–5. Nov 1996. doi:10.1042/bst0241001. PMID 8968500.
- "Regulation of second messengers by the inositol polyphosphate 5-phosphatases". Biochemical Society Transactions 24 (4): 994–1000. Nov 1996. doi:10.1042/bst0240994. PMID 8968499.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas". The International Journal of Biochemistry & Cell Biology 37 (11): 2273–83. Nov 2005. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
- "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics 72 (4): 918–30. Apr 2003. doi:10.1086/374320. PMID 12621583.
- "SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation". Molecular and Cellular Biology 23 (4): 1209–20. Feb 2003. doi:10.1128/MCB.23.4.1209-1220.2003. PMID 12556481.
- "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation". The Journal of Biological Chemistry 278 (13): 11376–85. Mar 2003. doi:10.1074/jbc.M209991200. PMID 12536145.
- "Identification and characterization of a novel inositol polyphosphate 5-phosphatase". The Journal of Biological Chemistry 275 (15): 10870–5. Apr 2000. doi:10.1074/jbc.275.15.10870. PMID 10753883.
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