Biology:SLCO2A1

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Solute carrier organic anion transporter family, member 2A1 also known as the prostaglandin transporter (PGT) is a protein that in humans is encoded by the SLCO2A1 gene.[1]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[1]

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[2]

References

  1. 1.0 1.1 "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=6578. Retrieved 2011-12-30. 
  2. "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy". American Journal of Human Genetics 90 (1): 125–32. January 2012. doi:10.1016/j.ajhg.2011.11.019. PMID 22197487. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.