Biology:SMTN
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 Generic protein structure example |
Smoothelin is a protein that in humans is encoded by the SMTN gene.[1][2][3]
This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.[3]
References
- ↑ "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 43 (2): 245–7. Sep 1997. doi:10.1006/geno.1997.9999. PMID 9244445.
- ↑ "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol 134 (2): 401–11. Sep 1996. doi:10.1083/jcb.134.2.401. PMID 8707825.
- ↑ 3.0 3.1 "Entrez Gene: SMTN smoothelin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525.
Further reading
- Luft FC (1999). "Differentiating one smooth operator from another.". J. Mol. Med. 77 (2): 255–7. doi:10.1007/s001090050347. PMID 10023778.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant.". Cell Struct. Funct. 22 (1): 65–72. 1997. doi:10.1247/csf.22.65. PMID 9113392.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "A novel isoform of the smooth muscle cell differentiation marker smoothelin.". J. Mol. Med. 77 (2): 294–8. 1999. doi:10.1007/s001090050352. PMID 10023782.
- "Smoothelin in adult and developing human arteries and myocardium.". Histochem. Cell Biol. 112 (4): 291–9. 2000. doi:10.1007/s004180050450. PMID 10550614.
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression.". FASEB J. 14 (1): 17–26. 2000. doi:10.1096/fasebj.14.1.17. PMID 10627276.
- "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle.". J. Vasc. Res. 38 (2): 120–32. 2001. doi:10.1159/000051039. PMID 11316948.
- "Expression of the smoothelin gene is mediated by alternative promoters.". Cardiovasc. Res. 55 (4): 850–63. 2002. doi:10.1016/S0008-6363(02)00491-1. PMID 12176134.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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