Biology:SPN1
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 Generic protein structure example |
Snurportin1 is a protein that in humans is encoded by the SNUPN gene.[1][2]
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[2]
References
- ↑ "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure". EMBO J 17 (14): 4114–26. Sep 1998. doi:10.1093/emboj/17.14.4114. PMID 9670026.
- ↑ 2.0 2.1 "Entrez Gene: SNUPN snurportin 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10073.
Further reading
- "CRM1-mediated recycling of snurportin 1 to the cytoplasm.". J. Cell Biol. 145 (2): 255–64. 1999. doi:10.1083/jcb.145.2.255. PMID 10209022.
- "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.". Hum. Mol. Genet. 11 (15): 1785–95. 2003. doi:10.1093/hmg/11.15.1785. PMID 12095920.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.". EMBO J. 24 (13): 2235–43. 2005. doi:10.1038/sj.emboj.7600701. PMID 15920472.
- "Cross-talk between snurportin1 subdomains.". Mol. Biol. Cell 16 (10): 4660–71. 2006. doi:10.1091/mbc.E05-04-0316. PMID 16030253.
- "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
External links
- SNUPN human gene location in the UCSC Genome Browser.
- SNUPN human gene details in the UCSC Genome Browser.
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