Biology:SSX4 (gene)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• "Molecular mechanisms underlying human synovial sarcoma development.". Genes Chromosomes Cancer 30 (1): 1–14. 2001. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G. PMID 11107170. 
• "SSX: a multigene family with several members transcribed in normal testis and human cancer.". Int. J. Cancer 72 (6): 965–71. 1997. doi:10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N. PMID 9378559. 
• "A novel fusion gene, SYT-SSX4, in synovial sarcoma.". J. Natl. Cancer Inst. 91 (11): 974–5. 1999. doi:10.1093/jnci/91.11.974. PMID 10359553. 
• "Expressions of cancer-testis antigens in human hepatocellular carcinomas.". Cancer Lett. 164 (2): 189–95. 2001. doi:10.1016/S0304-3835(01)00379-2. PMID 11179834. 
• "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression.". Gene 268 (1–2): 173–82. 2001. doi:10.1016/S0378-1119(01)00412-7. PMID 11368913. 
• "Clinical impact of molecular and cytogenetic findings in synovial sarcoma.". Genes Chromosomes Cancer 31 (4): 362–72. 2001. doi:10.1002/gcc.1155. PMID 11433527. 
• "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.". Genes Chromosomes Cancer 34 (3): 285–98. 2002. doi:10.1002/gcc.10073. PMID 12007189. 
• "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.". Oncogene 21 (26): 4181–90. 2002. doi:10.1038/sj.onc.1205569. PMID 12037676. 
• "The SSX gene family: characterization of 9 complete genes.". Int. J. Cancer 101 (5): 448–53. 2002. doi:10.1002/ijc.10634. PMID 12216073. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R. 
• "CD4+ T cell responses to SSX-4 in melanoma patients.". J. Immunol. 174 (8): 5092–9. 2005. doi:10.4049/jimmunol.174.8.5092. PMID 15814740. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.