Biology:STMN3

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Stathmin-3 is a protein that in humans is encoded by the STMN3 gene.[1][2][3]

Function

The protein encoded by this gene belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics.[3]

Interactions

STMN3 has been shown to interact with TRPC5.[4]

References

  1. "SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system". Journal of Neurochemistry 70 (6): 2386–96. June 1998. doi:10.1046/j.1471-4159.1998.70062386.x. PMID 9603203. 
  2. "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proceedings of the National Academy of Sciences of the United States of America 97 (3): 1230–5. February 2000. doi:10.1073/pnas.97.3.1230. PMID 10655513. Bibcode2000PNAS...97.1230B. 
  3. 3.0 3.1 "Entrez Gene: STMN3 stathmin-like 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50861. 
  4. "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nature Neuroscience 6 (8): 837–45. August 2003. doi:10.1038/nn1092. PMID 12858178. 

Further reading

  • "The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network". Journal of Cell Science 111 ( Pt 22) (22): 3333–46. November 1998. doi:10.1242/jcs.111.22.3333. PMID 9788875. 
  • "Stathmin family proteins display specific molecular and tubulin binding properties". The Journal of Biological Chemistry 276 (19): 16146–54. May 2001. doi:10.1074/jbc.M010637200. PMID 11278715. 
  • "Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP". Genomics 81 (4): 400–10. April 2003. doi:10.1016/S0888-7543(03)00031-4. PMID 12676564. 
  • "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nature Neuroscience 6 (8): 837–45. August 2003. doi:10.1038/nn1092. PMID 12858178.