Biology:SUMO3

Short description: Protein-coding gene in the species Homo sapiens

Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene.^[1]^[2]

Function

SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002).[supplied by OMIM]^[2]

Interactions

SUMO3 has been shown to interact with ARNTL^[3] and Thymine-DNA glycosylase.^[4]

References

↑ "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family". Genomics 40 (2): 362–6. March 1997. doi:10.1006/geno.1996.4556. PMID 9119407.
↑ ^2.0 ^2.1 "Entrez Gene: SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6612.
↑ "Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex". Molecular and Cellular Biology 28 (19): 6056–65. October 2008. doi:10.1128/MCB.00583-08. PMID 18644859.
↑ "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover". The EMBO Journal 21 (6): 1456–64. March 2002. doi:10.1093/emboj/21.6.1456. PMID 11889051.

"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
"Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3". The Journal of Biological Chemistry 275 (9): 6252–8. March 2000. doi:10.1074/jbc.275.9.6252. PMID 10692421.
"Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9". The Journal of Biological Chemistry 276 (38): 35368–74. September 2001. doi:10.1074/jbc.M104214200. PMID 11451954.
"Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2". Journal of Virology 76 (1): 232–42. January 2002. doi:10.1128/JVI.76.1.232-242.2002. PMID 11739688.
"Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin". Molecular and Cellular Biology 22 (11): 3803–19. June 2002. doi:10.1128/MCB.22.11.3803-3819.2002. PMID 11997515.
"Molecular features of human ubiquitin-like SUMO genes and their encoded proteins". Gene 296 (1–2): 65–73. August 2002. doi:10.1016/S0378-1119(02)00843-0. PMID 12383504.
"A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3". The Journal of Biological Chemistry 278 (11): 9134–41. March 2003. doi:10.1074/jbc.M210440200. PMID 12511558.
"Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3". The Journal of Biological Chemistry 278 (35): 33416–21. August 2003. doi:10.1074/jbc.M305680200. PMID 12810706.
"Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry 42 (33): 9959–69. August 2003. doi:10.1021/bi0345283. PMID 12924945.
"SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression". Genes & Development 17 (24): 3048–61. December 2003. doi:10.1101/gad.1153003. PMID 14701874.
"A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex". Structure 12 (8): 1519–31. August 2004. doi:10.1016/j.str.2004.05.023. PMID 15296745.
"Distinct in vivo dynamics of vertebrate SUMO paralogues". Molecular Biology of the Cell 15 (12): 5208–18. December 2004. doi:10.1091/mbc.E04-07-0589. PMID 15456902.
"Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1". The Biochemical Journal 386 (Pt 2): 325–30. March 2005. doi:10.1042/BJ20041210. PMID 15487983.
"Solution structure of human SUMO-3 C47S and its binding surface for Ubc9". Biochemistry 44 (8): 2790–9. March 2005. doi:10.1021/bi0477586. PMID 15723523.
"Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation". Molecular and Cellular Biology 25 (16): 6964–79. August 2005. doi:10.1128/MCB.25.16.6964-6979.2005. PMID 16055710.