Biology:Saturation (genetic)
From HandWiki
Genetic saturation is the result of multiple substitutions at the same site in a sequence, or identical substitutions in different sequence, such that the apparent sequence divergence rate is lower than the actual divergence that has occurred.[1] In phylogenetics, saturation effects result in long branch attraction, where the most distant lineages have misleadingly short branch lengths. It also decreases phylogenetic information contained in the sequences.[2] Genetic saturation occurs most rapidly on fast evolving sequences, such as the hypervariable region of mitochondrial DNA, or in Short tandem repeat such as on the Y-chromosome.[3][4]
See also
References
- ↑ "Resolving difficult phylogenetic questions: why more sequences are not enough". PLOS Biology 9 (3): e1000602. March 2011. doi:10.1371/journal.pbio.1000602. PMID 21423652.
- ↑ "[Case of "renal diabetes"]". Zdravookhranenie Kirgizii 26 (3): 49–51. 2003-01-01. doi:10.1016/S1055-7903(02)00326-3. PMID 7903.
- ↑ "Characterizing the time dependency of human mitochondrial DNA mutation rate estimates". Molecular Biology and Evolution 26 (1): 217–30. January 2009. doi:10.1093/molbev/msn244. PMID 18984905.
- ↑ "Time dependency of molecular rate estimates and systematic overestimation of recent divergence times". Molecular Biology and Evolution 22 (7): 1561–8. July 2005. doi:10.1093/molbev/msi145. PMID 15814826.
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