Biology:Secretagogin
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Secretagogin is a protein that in humans is encoded by the SCGN gene.[1][2]
Function
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.[2] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.
References
- ↑ Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
- ↑ 2.0 2.1 "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10590.
Further reading
- "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.". Cereb. Cortex 11 (12): 1161–9. 2002. doi:10.1093/cercor/11.12.1161. PMID 11709487.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404.
- Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.". Pituitary 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930.
- "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. 2005. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
- "Identification and characterization of secretagogin promoter activity.". Scand. J. Immunol. 64 (6): 639–45. 2007. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620.
- Romanov R. et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release.". EMBO Journal 34 (1): 36–54. doi:10.15252/embj.201488977. PMID 25430741.
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