Biology:Sjögren syndrome antigen B

Short description: Protein

Generic protein structure example

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.

See also

• La domain

Further reading

• "Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein". The Journal of Clinical Investigation 85 (5): 1566–74. May 1990. doi:10.1172/JCI114606. PMID 1692037. 
• "Characteristics and epitope mapping of a cloned human autoantigen La". Journal of Immunology 140 (9): 3212–8. May 1988. doi:10.4049/jimmunol.140.9.3212. PMID 2452201. 
• "At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach". European Journal of Immunology 18 (12): 2049–57. December 1988. doi:10.1002/eji.1830181227. PMID 2464497. 
• "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding". Nucleic Acids Research 17 (6): 2233–44. March 1989. doi:10.1093/nar/17.6.2233. PMID 2468131. 
• "Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III". The EMBO Journal 8 (3): 851–61. March 1989. doi:10.1002/j.1460-2075.1989.tb03446.x. PMID 2470590. 
• "Genomic structure and amino acid sequence domains of the human La autoantigen". The Journal of Biological Chemistry 263 (34): 18043–51. December 1988. doi:10.1016/S0021-9258(19)81321-2. PMID 3192525. 
• "Isolation and analysis of cDNA clones expressing human lupus La antigen". Proceedings of the National Academy of Sciences of the United States of America 82 (7): 2115–9. April 1985. doi:10.1073/pnas.82.7.2115. PMID 3856888. Bibcode: 1985PNAS...82.2115C. 
• "La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA". Journal of Virology 68 (11): 7001–7. November 1994. doi:10.1128/jvi.68.11.7001-7007.1994. PMID 7933082. 
• "One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome". The Journal of Experimental Medicine 180 (6): 2059–67. December 1994. doi:10.1084/jem.180.6.2059. PMID 7964483. 
• "Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes". Cell 88 (5): 707–15. March 1997. doi:10.1016/S0092-8674(00)81913-3. PMID 9054510. 
• "Human La protein: a stabilizer of histone mRNA". Molecular and Cellular Biology 17 (6): 3028–36. June 1997. doi:10.1128/mcb.17.6.3028. PMID 9154801. 
• "The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs". The Biochemical Journal 323 ( Pt 1) (1): 151–8. April 1997. doi:10.1042/bj3230151. PMID 9173875. 
• "T cell reactivity to Sjögren's syndrome related antigen La(SSB)". The Journal of Rheumatology 24 (12): 2340–7. December 1997. PMID 9415639. 
• "Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution". Biochemistry 39 (11): 3023–33. March 2000. doi:10.1021/bi992308c. PMID 10715123. 
• "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology 274 (2): 378–90. September 2000. doi:10.1006/viro.2000.0461. PMID 10964780. 
• "Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366". Molecular Cell 6 (2): 339–48. August 2000. doi:10.1016/S1097-2765(00)00034-4. PMID 10983981. 
• "The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs". Journal of Molecular Biology 312 (5): 975–84. October 2001. doi:10.1006/jmbi.2001.5026. PMID 11580243. 
• "Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA". Virology 295 (2): 337–47. April 2002. doi:10.1006/viro.2002.1407. PMID 12033793. 
• "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs". Molecular Cell 9 (5): 1113–23. May 2002. doi:10.1016/S1097-2765(02)00533-6. PMID 12049746. 
• "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology 320 (3): 475–88. July 2002. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904.