Biology:La domain
| La domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of the la domain of c-mpl binding protein | |||||||||
| Identifiers | |||||||||
| Symbol | La | ||||||||
| Pfam | PF05383 | ||||||||
| InterPro | IPR006630 | ||||||||
| SMART | TSPN | ||||||||
| PROSITE | PDOC00280 | ||||||||
| MEROPS | I75 | ||||||||
| SCOP2 | 2mpr / SCOPe / SUPFAM | ||||||||
| TCDB | 1.B.3 | ||||||||
| CDD | cd07323 | ||||||||
| |||||||||
In molecular biology, the La domain is a conserved protein domain. Human 60 kDa SS-A/Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjögren syndrome.[1] In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor.[2] In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation.[3] In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis.[4] The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and an RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif.[5]
Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses.[6]
References
- ↑ "A peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation and reveals a single tyrosine critical for La RNA binding and translation stimulation". J. Virol. 78 (7): 3763–76. April 2004. doi:10.1128/jvi.78.7.3763-3776.2004. PMID 15016896.
- ↑ "Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs". Mol. Cell 12 (5): 1301–7. November 2003. doi:10.1016/S1097-2765(03)00429-5. PMID 14636586.
- ↑ "Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein". Nat. Struct. Mol. Biol. 11 (4): 323–9. April 2004. doi:10.1038/nsmb747. PMID 15004549.
- ↑ Keene JD (December 2003). "Posttranscriptional generation of macromolecular complexes". Mol. Cell 12 (6): 1347–9. doi:10.1016/S1097-2765(03)00496-9. PMID 14690589.
- ↑ "La gets its wings". Nat. Struct. Mol. Biol. 11 (4): 303–5. April 2004. doi:10.1038/nsmb0404-303. PMID 15048103.
- ↑ "A yeast RNA binding protein that resembles the human autoantigen La". J. Mol. Biol. 245 (2): 81–5. January 1995. doi:10.1006/jmbi.1994.0008. PMID 7799435.
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