Biology:Syntaxin 3
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Syntaxin 3, also known as STX3, is a protein[1] which in humans is encoded by the STX3 gene.[2][3]
Function
The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.[2] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.[4] Mutations in Syntaxin 3 cause Microvillus inclusion disease.[5]
Interactions
Syntaxin 3 has been shown to interact with SNAP-25,[6][7][8] SNAP23[7][8][9][10] and SNAP29.[8]
References
- ↑ "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. June 1995. doi:10.1006/bbrc.1995.1910. PMID 7598732.
- ↑ 2.0 2.1 "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. March 1999. doi:10.1002/jlb.65.3.397. PMID 10080545. http://www.jleukbio.org/cgi/content/abstract/65/3/397.
- ↑ "Entrez Gene: STX3 syntaxin 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6809.
- ↑ "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature 440 (7085): 813–7. April 2006. doi:10.1038/nature04598. PMID 16598260. Bibcode: 2006Natur.440..813D.
- ↑ "Loss of syntaxin 3 causes variant microvillus inclusion disease". Gastroenterology 147 (1): 65–68.e10. 2014. doi:10.1053/j.gastro.2014.04.002. PMID 24726755.
- ↑ "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. Jun 1995. doi:10.1074/jbc.270.22.13022. PMID 7768895.
- ↑ 7.0 7.1 "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. 271 (23): 13300–3. Jun 1996. doi:10.1074/jbc.271.23.13300. PMID 8663154.
- ↑ 8.0 8.1 8.2 "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. Dec 1998. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- ↑ "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. Aug 2003. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
- ↑ "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. 234 (1): 257–62. May 1997. doi:10.1006/bbrc.1997.6560. PMID 9168999.
Further reading
- "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. 1995. doi:10.1006/bbrc.1995.1910. PMID 7598732.
- "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. 1995. doi:10.1074/jbc.270.22.13022. PMID 7768895.
- "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. 1995. doi:10.1038/375594a0. PMID 7791877. Bibcode: 1995Natur.375..594L.
- "A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina". J. Neurosci. 16 (21): 6713–21. 1996. doi:10.1523/JNEUROSCI.16-21-06713.1996. PMID 8824312.
- "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. 1997. doi:10.1074/jbc.272.10.6179. PMID 9045631.
- "Human syntaxin 3 is localized apically in human intestinal cells". J. Cell Sci. 110 (18): 2207–14. 1997. doi:10.1242/jcs.110.18.2207. PMID 9378770.
- "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. 1998. doi:10.1091/mbc.9.6.1437. PMID 9614185.
- "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell Sci. 111 (17): 2681–8. 1998. doi:10.1242/jcs.111.17.2681. PMID 9701566.
- "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. 1998. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. 1999. doi:10.1002/jlb.65.3.397. PMID 10080545.
- "Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties". J. Biol. Chem. 274 (22): 15440–6. 1999. doi:10.1074/jbc.274.22.15440. PMID 10336434. http://pubman.mpdl.mpg.de/pubman/item/escidoc:600498/component/escidoc:2224261/600498.pdf.
- "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell 10 (7): 2285–95. 1999. doi:10.1091/mbc.10.7.2285. PMID 10397765.
- "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. 2000. doi:10.1074/jbc.275.18.13476. PMID 10788461.
- "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. 2002. doi:10.1074/jbc.M208315200. PMID 12198139.
- "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. 2003. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
- "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx". J. Biol. Chem. 280 (13): 12908–16. 2005. doi:10.1074/jbc.M410013200. PMID 15623527.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Mol. Biol. Cell 17 (2): 977–89. 2006. doi:10.1091/mbc.E05-05-0462. PMID 16339081.
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