Biology:Synthetic ribosome

From HandWiki

Synthetic ribosomes are artificial small-molecules that can synthesize peptides in a sequence-specific matter.[1] David Alan Leigh's lab built synthetic ribosome using a chemical structure based on a rotaxane.[2]

The Cédric Orelle research group created ribosomes with tethered and inseparable subunits (or Ribo-T).[3]

References

  1. ↑ Sleator, RD (2013). "Synthetic ribosomes". Bioengineered 4 (2): 63–4. doi:10.4161/bioe.23640. PMID 23324614. 
  2. ↑ Lewandowski, B; De Bo, G; Ward, JW; Papmeyer, M; Kuschel, S; Aldegunde, MJ; Gramlich, PM; Heckmann, D et al. (2013). "Sequence-specific peptide synthesis by an artificial small-molecule machine". Science 339 (6116): 189–93. doi:10.1126/science.1229753. PMID 23307739. https://www.research.manchester.ac.uk/portal/en/publications/sequencespecific-peptide-synthesis-by-an-artificial-smallmolecule-machine(dc7b8f29-3915-46cd-93a5-1b2419ee7466).html. 
  3. ↑ Orelle, Cédric; Carlson, Erik D.; Szal, Teresa; Florin, Tanja; Jewett, Michael C.; Mankin, Alexander S. (2015). "Protein synthesis by ribosomes with tethered subunits". Nature 524 (7563): 119–124. doi:10.1038/nature14862. PMID 26222032. https://zenodo.org/record/894862. 



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