Biology:Szybalski's rule
From HandWiki
Szybalski's rule says that lower-protein particles like viruses contain more purines than pyrimidine in their nucleic acid sequence.[1] This is to prevent double-stranded RNA formation of one or two separate RNA strand that have complementary regions. The formation of a double-stranded RNA is not efficient for viruses as it may delay or stop RNA replication or protein formation.[2] The rule is named for Wacław Szybalski.
References
- ↑ "Pyrimidine clusters on the transcribing strand of DNA and their possible role in the initiation of RNA synthesis". Cold Spring Harb Symp Quant Biol 31: 123–127. 1966. doi:10.1101/SQB.1966.031.01.019. PMID 4966069.
- ↑ "Thermophilic Bacteria Strictly Obey Szybalski's Transcription Direction Rule and Politely Purine-Load RNAs with Both Adenine and Guanine". Genome Res 10 (2): 228–236. 2000. doi:10.1101/gr.10.2.228. PMID 10673280.
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