Biology:T-cell activation RhoGTPase activating protein

Generic protein structure example

T-cell activation RhoGTPase activating protein is a protein that in humans is encoded by the TAGAP gene.

Function

This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

Further reading

• "Newly identified genetic risk variants for celiac disease related to the immune response". Nat. Genet. 40 (4): 395–402. 2008. doi:10.1038/ng.102. PMID 18311140. 
• "Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease". J. Med. Genet. 46 (1): 60–3. 2009. doi:10.1136/jmg.2008.061457. PMID 18805825. 
• "Shared and distinct genetic variants in type 1 diabetes and celiac disease". N. Engl. J. Med. 359 (26): 2767–77. 2008. doi:10.1056/NEJMoa0807917. PMID 19073967. 
• "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut 58 (8): 1078–83. 2009. doi:10.1136/gut.2008.169052. PMID 19240061. https://research.vumc.nl/en/publications/9f0b4115-baf6-4bc6-ab6b-4fd7f23f0f0a. 
• "Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort". Genes Immun. 11 (1): 79–86. 2010. doi:10.1038/gene.2009.67. PMID 19693089. 
• "Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk". Nat. Genet. 41 (12): 1313–8. 2009. doi:10.1038/ng.479. PMID 19898481. 
• "Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis". Ann. Rheum. Dis. 69 (12): 2169–72. 2010. doi:10.1136/ard.2009.126938. PMID 20647273. 
• "Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease". Arthritis Res. Ther. 12 (5): R175. 2010. doi:10.1186/ar3139. PMID 20854658. 
• "Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease". Arthritis Res. Ther. 12 (5): R175. 2010. doi:10.1186/ar3139. PMID 20854658. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.