Biology:T-cell receptor excision circles
T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes. Their presence indicates maturation of T cells; TRECs are reduced in SCID (Severe combined immunodeficiency disease).
Signal joint T-cell receptor excision circles (sjTRECs) might be used as a way to test the age of the individual from a blood sample. The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).
- T cell receptor
- V(D)J recombination
- http://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html[full citation needed]
- Zhang, S. L.; Bhandoola, A. (2012). "Losing TREC with age". Immunity 36 (2): 163–165. doi:10.1016/j.immuni.2012.02.005. PMID 22365662.
- "Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA)". Journal of Immunological Methods 237 (1–2): 187–97. 2000. doi:10.1016/S0022-1759(00)00136-8. PMID 10725462.
Original source: https://en.wikipedia.org/wiki/ T-cell receptor excision circles. Read more