Biology:T1 holin family

Short description: Class of transmembrane transport proteins

The Phage T1 Holin (T1 Holin) Family (TC# 1.E.37) is represented in enterobacterial phages T1, RTP and F20, Klebsiella phage KP36, and Escherichia phage ADB-2. All of these possess a putative holin that share a high level of identity. Additionally, Gp9 of E. coli phage phiE49 is similar in sequence. These proteins are short, 55 to 71 amino acyl residues (aas) in length, and exhibit a single transmembrane segment (TMS). A representative list of proteins belonging to the T1 Holin family can be found in the Transporter Classification Database.

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Reddy, BL; Saier, MH (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochim. Biophys. Acta 1828 (11): 2654–71. doi:10.1016/j.bbamem.2013.07.004. PMID 23856191. .
• Saier, MH; Reddy, BL (2015). "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications". J. Bacteriol. 197 (1): 7–17. doi:10.1128/JB.02046-14. PMID 25157079. .
• Wang, IN; Smith, DL; Young, R (2000). "Holins: the protein clocks of bacteriophage infections". Annu. Rev. Microbiol. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145. .
• Young, R; Bläsi, U (1995). "Holins: form and function in bacteriophage lysis". FEMS Microbiol. Rev. 17 (1–2): 191–205. doi:10.1111/j.1574-6976.1995.tb00202.x. PMID 7669346. .

References

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