Biology:TDRD7
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.[1][2]
In melanocytic cells TDRD7 gene expression may be regulated by MITF.[3]
Gene polymorphism
Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.[4]
Interactions
TDRD7 has been shown to interact with TACC1.[5]
References
- ↑ "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Dec 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- ↑ "Entrez Gene: TDRD7 tudor domain containing 7". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23424.
- ↑ "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res 21 (6): 665–76. 2008. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- ↑ "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. Feb 2014. doi:10.1177/0300060513504702. PMID 24435515.
- ↑ "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene 22 (50): 8102–16. Nov 2003. doi:10.1038/sj.onc.1206972. PMID 14603251.
Further reading
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene 22 (50): 8102–16. 2003. doi:10.1038/sj.onc.1206972. PMID 14603251.
- "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. 2002. doi:10.1042/0264-6021:3630195. PMID 11903063.
- "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. 2001. doi:10.1006/bbrc.2001.5493. PMID 11527406.
- "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. 2000. doi:10.1046/j.1432-1327.2000.01218.x. PMID 10727952.
External links
- Overview of all the structural information available in the PDB for UniProt: Q8NHU6 (Human Tudor domain-containing protein 7) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q8K1H1 (Mouse Tudor domain-containing protein 7) at the PDBe-KB.
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