Biology:THOC1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]

Interactions

THOC1 has been shown to interact with Retinoblastoma protein.

Further reading

• "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing.". J. Cell Biol. 127 (3): 609–22. 1994. doi:10.1083/jcb.127.3.609. PMID 7525595. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution.". Genomics 83 (3): 493–501. 2004. doi:10.1016/j.ygeno.2003.08.017. PMID 14962675. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
• "The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.". FEBS Lett. 574 (1–3): 13–9. 2004. doi:10.1016/j.febslet.2004.07.074. PMID 15358532. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.". Mol. Cell. Biol. 25 (10): 4023–33. 2005. doi:10.1128/MCB.25.10.4023-4033.2005. PMID 15870275. 
• "Recruitment of the human TREX complex to mRNA during splicing.". Genes Dev. 19 (13): 1512–7. 2005. doi:10.1101/gad.1302205. PMID 15998806. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "Cancer cells and normal cells differ in their requirements for Thoc1.". Cancer Res. 67 (14): 6657–64. 2007. doi:10.1158/0008-5472.CAN-06-3234. PMID 17638875. 
• "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6.". Cancer Res. 67 (16): 7631–7. 2007. doi:10.1158/0008-5472.CAN-07-0334. PMID 17699767.