Biology:TRNP1
 Generic protein structure example |
TMF-regulated nuclear protein 1 is a nuclear protein that in humans is encoded by the TRNP1 gene. TRNP1 plays a crucial role in cellular proliferation and brain development.[1] Trnp1 is the first protein that has been shown to play a major role in cortical folding.[1] It represents a major stem cell factor, that is involved in crucial processes during brain but also stem cell development. Trnp1 controls gene expression levels and is sufficient to induce gyri and sulci in the developing brain. Local differences of Trnp1 expression levels in the human brain correlate with cortical folding.[1][2][3]
Function
Trnp1 binds to DNA with high affinity.[1] Its direct molecular function is unknown, it has no known molecular motif and therefore may represent a new class of molecules.[1]
Trnp1 has a very strong effect on cellular proliferation, Trnp1 dramatically increases the proliferation rate in vitro an in vivo.[1]
In addition to its stem cell function during brain development, there are data suggesting that Trnp1 might play a crucial role in cancer cells - Trnp1 has been described in gene expression analysis in cancer types.[4] the very strong proliferation capacity may be responsible for its oncogenic potential. Specifically, Trnp1 (together with other factors) serves as a biomarker for specific colon cancer subtypes.[4][5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate" (in English). Cell 153 (3): 535–49. April 2013. doi:10.1016/j.cell.2013.03.027. PMID 23622239.
- ↑ "Cerebral cortex expansion and folding: what have we learned?". The EMBO Journal 35 (10): 1021–44. May 2016. doi:10.15252/embj.201593701. PMID 27056680.
- ↑ "A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels". Nature Communications 7: 11812. June 2016. doi:10.1038/ncomms11812. PMID 27264089. Bibcode: 2016NatCo...711812M.
- ↑ 4.0 4.1 "Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype". Cancer Prevention Research 9 (6): 456–65. June 2016. doi:10.1158/1940-6207.CAPR-15-0363. PMID 27026680.
- ↑ Delker D, Kanth P, "Methods and compositions for predicting a colon cancer subtype", US patent application 20190032147, published 31 January 2019, assigned to University of Utah Research Foundation
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