Biology:TSUP family

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Short description: Proteins

The 4-Toluene Sulfonate Uptake Permease (TSUP) family (TC# 2.A.102) is also referred to as the TauE/SafE/YfcA/DUF81 Family.

Although its members have not been rigorously characterized, evidence is available that at least some members function in the transport of Sulfur containing Organic compounds. These include 4-toluene sulfonate which may be transported by the TsaS of Cupriavidus necator (TC# 2.A.102.1.1), sulfolactate which may be exported by the TauE protein of Cupriavidus necator (TC# 2.A.102.2.1) [1][2] and sulfoacetate which may be exported by the SafE1 protein of Neptuniibacter caesariensis (TC# 2.A.102.2.2).[3] Another member of the TSUP family, TsaS of Comamonas testosteroni, has been reported to function in the uptake of 4-toluene sulfonate.[4] None of these functional assignments can be considered to be certain.[5]

References

  1. Weinitschke, S; Denger, K; Cook, AM; Smits, TH (September 2007). "The DUF81 protein TauE in Cupriavidus necator H16, a sulfite exporter in the metabolism of C2 sulfonates.". Microbiology 153 (9): 3055–60. doi:10.1099/mic.0.2007/009845-0. PMID 17768248. 
  2. Mayer, J; Denger, K; Hollemeyer, K; Schleheck, D; Cook, AM (November 2012). "(R)-Cysteate-nitrogen assimilation by Cupriavidus necator H16 with excretion of 3-sulfolactate: a patchwork pathway.". Archives of Microbiology 194 (11): 949–57. doi:10.1007/s00203-012-0825-y. PMID 22797525. Bibcode2012ArMic.194..949M. https://zenodo.org/record/1239682. 
  3. Krejcík, Z; Denger, K; Weinitschke, S; Hollemeyer, K; Paces, V; Cook, AM; Smits, TH (August 2008). "Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.". Archives of Microbiology 190 (2): 159–68. doi:10.1007/s00203-008-0386-2. PMID 18506422. Bibcode2008ArMic.190..159K. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-67590. 
  4. Mampel, J; Maier, E; Tralau, T; Ruff, J; Benz, R; Cook, AM (October 1, 2004). "A novel outer-membrane anion channel (porin) as part of a putatively two-component transport system for 4-toluenesulphonate in Comamonas testosteroni T-2.". Biochemical Journal 383 (1): 91–9. doi:10.1042/bj20040652. PMID 15176949. 
  5. Saier, MH Jr.. "2.A.102. The 4-Toluene Sulfonate Uptake Permease (TSUP) Family". Saier Lab Bioinformatics Group. http://tcdb.org/search/result.php?tc=2.A.102. 

Further reading