Biology:Trefoil factor 2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.[1][2][3]
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.[3]
Glycan binding
All human trefoil factors are lectins that interact specifically with the disaccharide GlcNAc-α-1,4-Gal.[4] This disaccharide is an unusual glycotope that is only known to exist on the large, heavily glycosylated, mucins in the mucosa. By cross-linking mucins through the bivalent binding of this glycotope, the trefoil factors are then able to reversible modulate the thickness and viscosity of the mucus.[4]
References
- ↑ "The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2". Genomics 13 (4): 1328–30. Sep 1992. doi:10.1016/0888-7543(92)90059-2. PMID 1505966.
- ↑ "Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression". Eur J Hum Genet 4 (6): 308–15. May 1997. doi:10.1159/000472224. PMID 9043862.
- ↑ 3.0 3.1 "Entrez Gene: TFF2 trefoil factor 2 (spasmolytic protein 1)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7032.
- ↑ 4.0 4.1 "Trefoil factors share a lectin activity that defines their role in mucus". Nature Communications 11 (1). May 2020. doi:10.1038/s41467-020-16223-7. PMID 32404934. Bibcode: 2020NatCo..11.2265J.
Further reading
- "The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough.". Eur. Respir. J. 10 (8): 1892–906. 1997. doi:10.1183/09031936.97.10081892. PMID 9272936.
- "Ocular TFF-Peptides: New Mucus-Associated Secretory Products of Conjunctival Goblet Cells". Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology. 506. 2002. pp. 313–6. doi:10.1007/978-1-4615-0717-8_44. ISBN 978-1-4613-5208-2.
- "hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.". EMBO J. 9 (2): 407–14. 1990. doi:10.1002/j.1460-2075.1990.tb08125.x. PMID 2303034.
- "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.". J. Biol. Chem. 269 (44): 27269–74. 1994. doi:10.1016/S0021-9258(18)46979-7. PMID 7961636.
- "Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach.". Gastroenterology 105 (4): 1110–6. 1993. doi:10.1016/0016-5085(93)90956-d. PMID 8405856.
- "cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis.". Biochem. J. 318 (3): 939–44. 1996. doi:10.1042/bj3180939. PMID 8836141.
- "Close physical linkage of the genes encoding the pNR-2/pS2 protein and human spasmolytic protein (hSP).". Hum. Genet. 99 (3): 303–7. 1997. doi:10.1007/s004390050362. PMID 9050913.
- "The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.". Genomics 40 (1): 200–2. 1997. doi:10.1006/geno.1996.4511. PMID 9070946.
- "A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: polymorphism and mammalian evolution.". Eur. J. Hum. Genet. 6 (2): 121–8. 1998. doi:10.1038/sj.ejhg.5200166. PMID 9781055.
- "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.". Neuropeptides 32 (3): 215–23. 1999. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055.
- "The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach.". Gut 46 (4): 454–9. 2000. doi:10.1136/gut.46.4.454. PMID 10716671.
- "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
- "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.". Genomics 68 (1): 22–9. 2001. doi:10.1006/geno.2000.6253. PMID 10950923.
- "Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element.". Biochem. Biophys. Res. Commun. 293 (1): 366–74. 2002. doi:10.1016/S0006-291X(02)00199-7. PMID 12054609. Bibcode: 2002BBRC..293..366B.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa.". World J. Gastroenterol. 9 (5): 910–4. 2003. doi:10.3748/wjg.v9.i5.910. PMID 12717829.
 |  |
