Biology:Tuberous sclerosis complex tumor suppressors
From HandWiki
Tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth.[1] A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex.[1] Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes.[2]
Resistance to ischemia-reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex.[3]
References
- ↑ 1.0 1.1 "TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1". Molecular Cell 47 (4): 535–546. 2012. doi:10.1016/j.molcel.2012.06.009. PMID 22795129.
- ↑ "Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome". Cell 156 (4): 771–785. 2014. doi:10.1016/j.cell.2013.11.049. PMID 24529379.
- ↑ "The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo". Cell Reports 8 (4): 1160–1170. 2014. doi:10.1016/j.celrep.2014.07.018. PMID 25131199.
 |  |
