Biology:UBXD5
 Generic protein structure example |
UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.[1][2]
Function
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymorphic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
Interactions
UBXD5 has been shown to interact with Rnd1,[1] Rnd2[1] and Rnd3.[1]
References
- ↑ 1.0 1.1 1.2 1.3 "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. Apr 2002. doi:10.1128/MCB.22.9.2952-2964.2002. PMID 11940653.
- ↑ 2.0 2.1 "Entrez Gene: UBXD5 UBX domain containing 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91544.
Further reading
- "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes". Cancer Res. 63 (20): 6735–43. 2003. PMID 14583468.
- "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation". Biochem. Biophys. Res. Commun. 337 (2): 615–20. 2005. doi:10.1016/j.bbrc.2005.09.097. PMID 16202387.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
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