Biology:UFD1L
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Ubiquitin fusion degradation protein 1 homolog is a protein that in humans is encoded by the UFD1L gene.[1][2]
Function
The protein encoded by this gene forms a complex with two other proteins, NPL4 and VCP, that is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]
Interactions
UFD1L has been shown to interact with NPLOC4.[3][4]
References
- ↑ "UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome". Hum. Mol. Genet. 6 (2): 259–65. August 1997. doi:10.1093/hmg/6.2.259. PMID 9063746.
- ↑ 2.0 2.1 "Entrez Gene: UFD1L ubiquitin fusion degradation 1 like (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7353.
- ↑ "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene 275 (1): 39–46. September 2001. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
- ↑ "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. August 2008. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L)". Biochim. Biophys. Acta 1396 (2): 158–62. 1998. doi:10.1016/s0167-4781(97)00211-x. PMID 9540831.
- "A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects". Science 283 (5405): 1158–61. 1999. doi:10.1126/science.283.5405.1158. PMID 10024240. Bibcode: 1999Sci...283.1158Y.
- "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene 275 (1): 39–46. 2001. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
- "Functional characterization of the 5' flanking region of human ubiquitin fusion degradation 1 like gene (UFD1L)". Cell Biochem. Funct. 20 (2): 163–70. 2002. doi:10.1002/cbf.966. PMID 11979512.
- "Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies". Cell Biochem. Funct. 21 (3): 263–7. 2003. doi:10.1002/cbf.1021. PMID 12910480.
- "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature 429 (6994): 841–7. 2004. doi:10.1038/nature02656. PMID 15215856. Bibcode: 2004Natur.429..841Y.
- "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. 2004. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. 2005. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation". Biochem. Biophys. Res. Commun. 355 (4): 1087–90. 2007. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
- "Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase". Cell Metab. 6 (2): 115–28. 2007. doi:10.1016/j.cmet.2007.07.002. PMID 17681147.
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