Biology:UGT1A@
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UDP glucuronosyltransferase 1 family, polypeptide A cluster, also known as UGT1A@, is a human gene.[1]
This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.[1]
References
Further reading
- Mackenzie PI; Owens IS; Burchell B et al. (1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
- "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. 2000. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
- "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. 2001. doi:10.2174/1389200003339171. PMID 11465080.
- Ritter JK; Chen F; Sheen YY et al. (1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J. Biol. Chem. 267 (5): 3257–61. PMID 1339448.
- Gong QH; Cho JW; Huang T et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
- Kaplan M; Hammerman C; Rubaltelli FF et al. (2002). "Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism". Hepatology 35 (4): 905–11. doi:10.1053/jhep.2002.32526. PMID 11915038.
- "Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome". J. Hepatol. 38 (1): 3–8. 2003. doi:10.1016/S0168-8278(02)00306-9. PMID 12480553.
- "Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation". Genome Res. 14 (1): 79–89. 2004. doi:10.1101/gr.1225204. PMID 14672974.
- Giuliani L; Ciotti M; Stoppacciaro A et al. (2005). "UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry". Oncol. Rep. 13 (2): 185–91. doi:10.3892/or.13.2.185. PMID 15643497.
- Mercke Odeberg J; Andrade J; Holmberg K et al. (2007). "UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females". Eur. J. Clin. Pharmacol. 62 (10): 829–37. doi:10.1007/s00228-006-0166-3. PMID 16909274.
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