Biology:Ure2 internal ribosome entry site (IRES)
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In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of Ure2. It allows 5' cap- and eIF4E-independent translation of an N-terminally truncated form of Ure2. This truncated form lacks the prion-forming domain.[1] It is a 104 nucleotide region, smaller than most viral IRES elements, which forms a stem-loop structure.[2] EIF2A represses this IRES resulting in an inhibition of translation of the N-terminally truncated Ure2.[3][4]
See also
References
- ↑ Komar, AA; Lesnik, T; Cullin, C; Merrick, WC; Trachsel, H; Altmann, M (Mar 3, 2003). "Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3 propagation in yeast cells."]. The EMBO Journal 22 (5): 1199–209. doi:10.1093/emboj/cdg103. PMID 12606584.
- ↑ Reineke, LC; Komar, AA; Caprara, MG; Merrick, WC (Jul 4, 2008). "A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae.". The Journal of Biological Chemistry 283 (27): 19011–25. doi:10.1074/jbc.M803109200. PMID 18460470.
- ↑ Komar, AA; Gross, SR; Barth-Baus, D; Strachan, R; Hensold, JO; Goss Kinzy, T; Merrick, WC (Apr 22, 2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A.". The Journal of Biological Chemistry 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.
- ↑ Reineke, LC; Cao, Y; Baus, D; Hossain, NM; Merrick, WC (2011). "Insights into the role of yeast eIF2A in IRES-mediated translation.". PLOS ONE 6 (9): e24492. doi:10.1371/journal.pone.0024492. PMID 21915340. Bibcode: 2011PLoSO...624492R.
Further reading
- Reineke, LC; Merrick, WC (December 2009). "Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression.". RNA 15 (12): 2264–77. doi:10.1261/rna.1722809. PMID 19861427.
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