Biology:Uroplakin-1a
 Generic protein structure example |
Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.[1][2][3]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins.
UP1a may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.[3]
References
- ↑ "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol 153 (6): 1957–67. Dec 1998. doi:10.1016/S0002-9440(10)65709-4. PMID 9846985.
- ↑ "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int J Urol 6 (6): 286–92. Sep 1999. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304.
- ↑ 3.0 3.1 "Entrez Gene: UPK1A uroplakin 1A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11045.
Further reading
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- "Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins". J. Cell Biol. 125 (1): 171–82. 1994. doi:10.1083/jcb.125.1.171. PMID 8138569.
- "Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells". J. Biol. Chem. 270 (50): 29752–9. 1996. doi:10.1074/jbc.270.50.29752. PMID 8530366.
- "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. 1999. doi:10.1016/S0002-9440(10)65206-6. PMID 10514386.
- "High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma". Jpn. J. Cancer Res. 93 (5): 523–31. 2003. doi:10.1111/j.1349-7006.2002.tb01287.x. PMID 12036448.
- "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell 13 (12): 4221–30. 2003. doi:10.1091/mbc.E02-04-0211. PMID 12475947.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "Molecular cloning and expression of uroplakins in transitional cell carcinoma". Bladder Disease, Part A. 539. 2004. 33–46. doi:10.1007/978-1-4419-8889-8_3. ISBN 978-1-4613-4707-1.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Transcriptional control of the human urothelial-specific gene, uroplakin Ia". Biochim. Biophys. Acta 1729 (2): 126–34. 2005. doi:10.1016/j.bbaexp.2005.04.004. PMID 15913809.
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