Biology:VANGL2
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VANGL planar cell polarity protein 2 is a protein that in humans is encoded by the VANGL2 gene.
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Function
The protein encoded by the VANGL2 gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011].
References
Further reading
- "Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot". J. Int. Med. Res. 35 (6): 867–72. 2007. doi:10.1177/147323000703500614. PMID 18034999.
- "The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion". Cancer Lett. 287 (1): 54–61. January 2010. doi:10.1016/j.canlet.2009.05.041. PMID 19577357.
- "The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis". Hum. Mol. Genet. 19 (11): 2251–67. June 2010. doi:10.1093/hmg/ddq104. PMID 20223754.
- "VANGL2 mutations in human cranial neural-tube defects". N. Engl. J. Med. 362 (23): 2232–5. June 2010. doi:10.1056/NEJMc0910820. PMID 20558380.
- "VANGL2 mutations in human cranial neural-tube defects". N. Engl. J. Med. 362 (23): 2232–5. June 2010. doi:10.1056/NEJMc0910820. PMID 20558380.
- "Contribution of VANGL2 mutations to isolated neural tube defects". Clin. Genet. 80 (1): 76–82. July 2011. doi:10.1111/j.1399-0004.2010.01515.x. PMID 20738329.
- "Loss of membrane targeting of Vangl proteins causes neural tube defects". Biochemistry 50 (5): 795–804. February 2011. doi:10.1021/bi101286d. PMID 21142127.
- "A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network". eLife 2: e00160. January 2013. doi:10.7554/eLife.00160. PMID 23326640.
- "Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers". Br. J. Cancer 108 (8): 1750–6. April 2013. doi:10.1038/bjc.2013.142. PMID 23579212.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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