Biology:VCX
 Generic protein structure example |
Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.[1][2][3]
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[3]
References
- ↑ "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet 9 (2): 311–9. Feb 2000. doi:10.1093/hmg/9.2.311. PMID 10607842.
- ↑ "A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation". Am J Hum Genet 67 (3): 563–73. Sep 2000. doi:10.1086/303047. PMID 10903929.
- ↑ 3.0 3.1 "Entrez Gene: VCX variable charge, X-linked". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609.
Further reading
- Zou SW; Zhang JC; Zhang XD et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis". Cell Res. 13 (3): 171–7. doi:10.1038/sj.cr.7290161. PMID 12862317.
- Sy SM; Wong N; Mok TS et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity". Lung Cancer 41 (1): 91–9. doi:10.1016/S0169-5002(03)00138-7. PMID 12826317.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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