Biology:VPS11
From HandWiki
 Generic protein structure example |
Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.[1]
Function
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[1]
Interactions
VPS11 has been shown to interact with VPS18,[2] VPS33A[2] and STX7.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55823.
- ↑ 2.0 2.1 2.2 "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. August 2001. doi:10.1074/jbc.M101778200. PMID 11382755.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.". Gene 264 (2): 241–7. 2001. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
- "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.". J. Biol. Chem. 276 (31): 29393–402. 2001. doi:10.1074/jbc.M101778200. PMID 11382755.
- "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.". Biochem. Biophys. Res. Commun. 311 (3): 577–82. 2004. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
- "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. 2004. doi:10.1101/gr.2122004. PMID 15231747.
- "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. 2004. doi:10.1073/pnas.0404089101. PMID 15498874.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.
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