Biology:Vascular endothelial growth factor B

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Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene.[1] VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.

Function

In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions.[2] VEGF-B plays also an important role on several types of neurons. It is important for the protection of neurons in the retina[3] and the cerebral cortex during stroke[4] and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.[5]

VEGF-B exerts its effects via the FLT1 receptor.[6]

VEGF-B has also been found to control endothelial uptake and transport of fatty acids in heart and skeletal muscle.[7][8]

Interactions

Vascular endothelial growth factor B has been shown to interact with FLT1.[9][10]

References

  1. ↑ "Entrez Gene: VEGFB vascular endothelial growth factor B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7423. 
  2. ↑ "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (15): 6152–7. April 2009. doi:10.1073/pnas.0813061106. PMID 19369214. 
  3. ↑ "VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats". J. Clin. Invest. 118 (3): 913–23. March 2008. doi:10.1172/JCI33673. PMID 18259607. 
  4. ↑ "Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice". J. Cereb. Blood Flow Metab. 24 (10): 1146–52. October 2004. doi:10.1097/01.wcb.0000134477.38980.38. PMID 15529014. 
  5. ↑ "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". J. Neurosci. 28 (42): 10451–9. October 2008. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022. 
  6. ↑ "Molecular and functional diversity of vascular endothelial growth factors". Mol. Divers. 10 (4): 515–27. November 2006. doi:10.1007/s11030-006-9027-3. PMID 16972015. 
  7. ↑ Muoio DM (July 2010). "Metabolism and vascular fatty acid transport". N. Engl. J. Med. 363 (3): 291–3. doi:10.1056/NEJMcibr1005397. PMID 20647206. 
  8. ↑ "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes". Nature 490 (7420): 426–30. October 2012. doi:10.1038/nature11464. PMID 23023133. 
  9. ↑ "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11709–14. September 1998. doi:10.1073/pnas.95.20.11709. PMID 9751730. 
  10. ↑ "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. 274 (30): 21217–22. July 1999. doi:10.1074/jbc.274.30.21217. PMID 10409677. 

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Vascular endothelial growth factor B





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