Biology:Vesicular glutamate transporter 3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Vesicular glutamate transporter 3 (VGLUT3) is a protein that in humans is encoded by the SLC17A8 gene.[1]
Function
This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.[1]
Clinical significance
Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[2][3]
References
- ↑ 1.0 1.1 "Entrez Gene: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=246213.
- ↑ Online Mendelian Inheritance in Man (OMIM) 605583
- ↑ "Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice". Am. J. Hum. Genet. 83 (2): 278–92. August 2008. doi:10.1016/j.ajhg.2008.07.008. PMID 18674745.
Further reading
- "DFNA25, a novel locus for dominant nonsyndromic hereditary hearing impairment, maps to 12q21-24.". Am. J. Hum. Genet. 68 (1): 254–60. 2001. doi:10.1086/316925. PMID 11115382.
- Fremeau RT; Voglmaier S; Seal RP; Edwards RH (2004). "VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate.". Trends Neurosci. 27 (2): 98–103. doi:10.1016/j.tins.2003.11.005. PMID 15102489.
- Seal RP; Edwards RH (2006). "The diverse roles of vesicular glutamate transporter 3". Neurotransmitter Transporters. Handbook of Experimental Pharmacology. 175. pp. 137–50. doi:10.1007/3-540-29784-7_7. ISBN 3-540-29783-9.
- "Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.". Am. J. Hum. Genet. 83 (2): 278–92. 2008. doi:10.1016/j.ajhg.2008.07.008. PMID 18674745.
- "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.". Protein Sci. 16 (9): 1819–29. 2007. doi:10.1110/ps.072944707. PMID 17660252.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Distribution of vesicular glutamate transporters in rat and human retina.". Brain Res. 1082 (1): 73–85. 2006. doi:10.1016/j.brainres.2006.01.111. PMID 16516863.
- Linke N et al. (2008). "Developmental pattern of three vesicular glutamate transporters in the myenteric plexus of the human fetal small intestine.". Histol. Histopathol. 23 (8): 979–86. PMID 18498073.
- Takamori S; Malherbe P; Broger C; Jahn R (2002). "Molecular cloning and functional characterization of human vesicular glutamate transporter 3.". EMBO Rep. 3 (8): 798–803. doi:10.1093/embo-reports/kvf159. PMID 12151341.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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