Biology:WASF3
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 Generic protein structure example |
Wiskott-Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.[1][2]
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.[2]
References
- ↑ "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun 260 (1): 296–302. Jul 1999. doi:10.1006/bbrc.1999.0894. PMID 10381382.
- ↑ 2.0 2.1 "Entrez Gene: WASF3 WAS protein family, member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810.
Further reading
- Jones GE (2000). "Cellular signaling in macrophage migration and chemotaxis". J. Leukoc. Biol. 68 (5): 593–602. doi:10.1189/jlb.68.5.593. PMID 11073096.
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "A candidate tumor suppressor gene in human breast cancers". Cancer Res. 54 (6): 1393–6. 1994. PMID 8137235.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development". J. Cell Biol. 142 (5): 1325–35. 1998. doi:10.1083/jcb.142.5.1325. PMID 9732292.
- "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. 1999. doi:10.1093/dnares/5.6.355. PMID 10048485.
- "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nat. Cell Biol. 3 (1): 76–82. 2001. doi:10.1038/35050590. PMID 11146629.
- "The Wiskott-Aldrich syndrome protein (WASP) family". Trends Biochem. Sci. 26 (3): 198–9. 2001. doi:10.1016/S0968-0004(01)01788-1. PMID 11246027.
- "WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma". Oncogene 21 (38): 5967–74. 2002. doi:10.1038/sj.onc.1205734. PMID 12185600.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Genomic organization and expression profile of the human and mouse WAVE gene family". Mamm. Genome 14 (5): 314–22. 2003. doi:10.1007/s00335-002-2247-7. PMID 12856283.
- "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "WAVE/Scars in platelets". Blood 105 (8): 3141–8. 2005. doi:10.1182/blood-2003-04-1319. PMID 15280206.
- "Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage". J. Thromb. Haemost. 3 (2): 361–8. 2005. doi:10.1111/j.1538-7836.2004.01082.x. PMID 15670045.
- "Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2". BMC Cell Biol. 6 (1): 11. 2006. doi:10.1186/1471-2121-6-11. PMID 15752430.
- "WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase". J. Biol. Chem. 280 (23): 21748–55. 2005. doi:10.1074/jbc.M500503200. PMID 15826941.
- "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression". Exp. Cell Res. 308 (1): 135–45. 2005. doi:10.1016/j.yexcr.2005.04.011. PMID 15907837.
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