Biology:WD repeat domain 18
 Generic protein structure example |
WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene.
[1]
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP1, TEX10 called the rixosome which is involved in RNA degradation.[2][3] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA.[4]
References
- ↑ "Entrez Gene: WD repeat domain 18". https://www.ncbi.nlm.nih.gov/gene/57418.
- ↑ "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell 23 (4): 716–728. February 2012. doi:10.1091/mbc.E11-06-0530. PMID 22190735.
- ↑ "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife 9. June 2020. doi:10.7554/eLife.54341. PMID 32491985.
- ↑ "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature 604 (7904): 167–174. April 2022. doi:10.1038/s41586-022-04598-0. PMID 35355014. Bibcode: 2022Natur.604..167Z.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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