Biology:Zinc finger protein basonuclin-2
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 Generic protein structure example |
Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2 gene.[1][2] BCN2 has recently been shown to influence skin pigmentation levels in Europeans.[3] Genomic region spanning the BCN2 gene has 60% Neanderthal DNA sequence.[4]
See also
- Chromosome 9 (human)
- Zinc finger protein
References
- ↑ "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics 36 (1): 40–5. Jan 2004. doi:10.1038/ng1285. PMID 14702039.
- ↑ "Entrez Gene: BNC2 basonuclin 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54796.
- ↑ "Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans". Human Genetics 132 (2): 147–58. Feb 2013. doi:10.1007/s00439-012-1232-9. PMID 23052946.
- ↑ "Small Amounts of Archaic Admixture Provide Big Insights into Human History". Cell 163 (2): 281–4. Oct 2015. doi:10.1016/j.cell.2015.09.042. PMID 26451479.
Further reading
- "The human basonuclin 2 gene has the potential to generate nearly 90,000 mRNA isoforms encoding over 2000 different proteins". Genomics 89 (1): 44–58. Jan 2007. doi:10.1016/j.ygeno.2006.07.006. PMID 16942855.
- "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions". Proceedings of the National Academy of Sciences of the United States of America 103 (33): 12423–8. Aug 2006. doi:10.1073/pnas.0605086103. PMID 16891417. Bibcode: 2006PNAS..10312423V.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. Jan 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Molecular Cell 18 (6): 623–35. Jun 2005. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
- "Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes". Genomics 83 (5): 821–33. May 2004. doi:10.1016/j.ygeno.2003.11.009. PMID 15081112.
- "Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin". Proceedings of the National Academy of Sciences of the United States of America 101 (10): 3468–73. Mar 2004. doi:10.1073/pnas.0400268101. PMID 14988505. Bibcode: 2004PNAS..101.3468V.
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