Biology:Zyxin
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zyxin is a protein that in humans is encoded by the ZYX gene.[1][2][3]
Function
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.[3]
Interactions
Zyxin has been shown to interact with:
- Actinin, alpha 1[4][5]
- ENAH,[6][7]
- LASP1,[8]
- LATS1,[9] and
- Vasodilator-stimulated phosphoprotein.[7][10]
References
- ↑ "A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts". Eur J Biochem 241 (2): 657–63. January 1997. doi:10.1111/j.1432-1033.1996.00657.x. PMID 8917469.
- ↑ "Molecular characterization of human zyxin". J Biol Chem 271 (49): 31470–8. January 1997. doi:10.1074/jbc.271.49.31470. PMID 8940160.
- ↑ 3.0 3.1 "Entrez Gene: ZYX zyxin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7791.
- ↑ "An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment". J. Biol. Chem. 274 (19): 13410–8. May 1999. doi:10.1074/jbc.274.19.13410. PMID 10224105.
- ↑ "Analysis of the alpha-actinin/zyxin interaction". J. Biol. Chem. 276 (36): 33328–35. September 2001. doi:10.1074/jbc.M100789200. PMID 11423549.
- ↑ "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. June 2003. doi:10.1074/jbc.M301447200. PMID 12672821.
- ↑ 7.0 7.1 "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. July 2000. doi:10.1074/jbc.M001698200. PMID 10801818.
- ↑ "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J. Biol. Chem. 279 (19): 20401–10. May 2004. doi:10.1074/jbc.M310304200. PMID 15004028.
- ↑ "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor". J. Cell Biol. 149 (5): 1073–86. May 2000. doi:10.1083/jcb.149.5.1073. PMID 10831611.
- ↑ "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. 275 (40): 30817–25. October 2000. doi:10.1074/jbc.M005066200. PMID 10882740.
Further reading
- "Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein)". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7956–60. 1995. doi:10.1073/pnas.92.17.7956. PMID 7644520. Bibcode: 1995PNAS...92.7956R.
- "Gene encoding a mammalian epididymal protein". Biochem. Mol. Biol. Int. 34 (6): 1131–6. 1995. PMID 7696985.
- "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene 12 (7): 1577–81. 1996. PMID 8622875.
- "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells". J. Biol. Chem. 272 (47): 29407–10. 1997. doi:10.1074/jbc.272.47.29407. PMID 9367993.
- "Assignment of the ZYX gene for the LIM protein zyxin to human chromosome bands 7q34→q35 by in situ hybridization". Cytogenet. Cell Genet. 81 (3–4): 283–4. 1998. doi:10.1159/000015047. PMID 9730620.
- "Gene encoding a human testis Sertoli cell component related to LIM domain protein". Biochem. Mol. Biol. Int. 46 (1): 11–9. 1998. doi:10.1080/15216549800203502. PMID 9784834.
- "An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment". J. Biol. Chem. 274 (19): 13410–8. 1999. doi:10.1074/jbc.274.19.13410. PMID 10224105.
- "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. 2000. doi:10.1074/jbc.M001698200. PMID 10801818.
- "Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with H-Warts/Lats1 Tumor Suppressor". J. Cell Biol. 149 (5): 1073–86. 2000. doi:10.1083/jcb.149.5.1073. PMID 10831611.
- "Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I". J. Biol. Chem. 275 (33): 25723–32. 2000. doi:10.1074/jbc.M909632199. PMID 10851246.
- "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. 275 (40): 30817–25. 2000. doi:10.1074/jbc.M005066200. PMID 10882740.
- "BSPRY, a novel protein of the Ro-Ret family". Biochim. Biophys. Acta 1493 (1–2): 255–8. 2000. doi:10.1016/s0167-4781(00)00167-6. PMID 10978534.
- "Analysis of the alpha-actinin/zyxin interaction". J. Biol. Chem. 276 (36): 33328–35. 2001. doi:10.1074/jbc.M100789200. PMID 11423549.
- "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human Papillomavirus Type 6 Results in Its Nuclear Translocation". J. Virol. 75 (23): 11791–802. 2001. doi:10.1128/JVI.75.23.11791-11802.2001. PMID 11689660.
- "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. 2002. doi:10.1074/jbc.M106922200. PMID 11782456.
- "Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes". J. Invest. Dermatol. 118 (2): 246–54. 2002. doi:10.1046/j.0022-202x.2001.01657.x. PMID 11841540.
External links
- Zyxin Info with links in the Cell Migration Gateway
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