Chemistry:3,5-Difluoro-4-hydroxybenzylidene imidazolinone

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3,5-Difluoro-4-hydroxybenzylidene imidazolinone
DFHBI.png
Names
IUPAC name
(5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one[2]
Other names
  • DFHBI
  • 3,5-Difluoro-4-hydroxybenzylidene imidazolidinone
  • (Z)-4-(3,5-Difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one[1]
Identifiers
3D model (JSmol)
ChemSpider
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

3,5-Difluoro-4-hydroxybenzylidene imidazolinone or DFHBI[2] is an imidazolinone fluorophore used in various biochemical studies. The benzene ring of DFHBI can freely rotate around the single bond but when it is fixed in planar conformation, DFHBI fluoresces.[1] It is a synthetic analog of the GFP fluorophore.

References

  1. ↑ 1.0 1.1 Dou, Jiayi; Vorobieva, Anastassia A.; Sheffler, William; Doyle, Lindsey A.; Park, Hahnbeom; Bick, Matthew J.; Mao, Binchen; Foight, Glenna W. et al. (September 2018). "De novo design of a fluorescence-activating β-barrel" (in en). Nature 561 (7724): 485–491. doi:10.1038/s41586-018-0509-0. ISSN 0028-0836. PMID 30209393. Bibcode: 2018Natur.561..485D. 
  2. ↑ 2.0 2.1 "DFHBI 1241390-29-3". https://www.sigmaaldrich.com/CZ/en/product/sigma/sml1627. 



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