Chemistry:Astatobenzene
From HandWiki
Astatobenzene is an organoastatine chemical compound with the formula C
6H
5At. This is a compound in which an astatine atom, the rarest halogen, is bonded to a benzene ring. [1]
Synthesis
Several methods of obtaining astatobenzene are described.[2][3][4]
Homogeneous exchange between iodobenzene and astatine iodide at room temperature:
- C
6H
5I + AtI → C
6H
5At + I
2
Also, synthesis from phenylhydrazine and astatine iodide:
- C
6H
5NHNH
2 + AtI + I
2 → C
6H
5At + N
2 + 3 HI
Also, thermal decomposition of diphenyliodonium iodide containing diphenyliodonium astatide:
- (C
6H
5)
2IAt → C
6H
5At + C
6H
5I
Uses
The compound is of scientific interest primarily in research contexts involving astatine chemistry and radiopharmaceutical applications, where astatine radioactive isotopes are used.[5][6]
References
- ↑ Hirata, Saki; Mishiro, Kenji; Washiyama, Kohshin; Munekane, Masayuki; Fuchigami, Takeshi; Arano, Yasushi; Takahashi, Kazuhiro; Kinuya, Seigo et al. (23 January 2025). "In Vivo Stability Improvement of Astatobenzene Derivatives by Introducing Neighboring Substituents". Journal of Medicinal Chemistry 68 (2): 1540–1552. doi:10.1021/acs.jmedchem.4c02188. ISSN 0022-2623. PMID 39757786. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02188. Retrieved 1 September 2025.
- ↑ Samson, G.; Aten, A. H. W. (1 June 1970). "Syntheses of Astatobenzene" (in en). Radiochimica Acta 13 (4): 220–221. doi:10.1524/ract.1970.13.4.220. ISSN 2193-3405. https://www.degruyterbrill.com/document/doi/10.1524/ract.1970.13.4.220/html?srsltid=AfmBOopDYaSiSZBfScqrkowX0r5-h5MALjDlaf0nZchsvuPLw9EzM5f9. Retrieved 1 September 2025.
- ↑ (in en) Advances in Inorganic Chemistry. Academic Press. 27 May 1987. p. 58. ISBN 978-0-08-057880-4. https://books.google.com/books?id=K5_LSQqeZ_IC&dq=Astatobenzene&pg=PA58. Retrieved 1 September 2025.
- ↑ Kugler, Hans K.; Keller, Cornelius (9 March 2013) (in en). At Astatine. Springer Science & Business Media. p. 239. ISBN 978-3-662-05868-8. https://books.google.com/books?id=BYrqCAAAQBAJ&dq=Astatobenzene&pg=PA239. Retrieved 1 September 2025.
- ↑ Vásaros, L.; Berei, K.; Norseyev, Yu V. (1 June 1989). "Some Replacement and Addition Reactions of Astatine" (in en). Radiochimica Acta 47 (2–3): 119–128. doi:10.1524/ract.1989.47.23.119. ISSN 2193-3405. https://www.degruyterbrill.com/document/doi/10.1524/ract.1989.47.23.119/pdf?licenseType=restricted. Retrieved 1 September 2025.
- ↑ Hagen, A. P. (17 September 2009) (in en). Inorganic Reactions and Methods, The Formation of Bonds to Halogens (Part 1). John Wiley & Sons. p. 426. ISBN 978-0-470-14538-8. https://books.google.com/books?id=zVIpX7rkk7oC&dq=Astatobenzene&pg=PA426. Retrieved 1 September 2025.
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