Chemistry:Biotinylated retinoids
From HandWiki
Biotinylated retinoids are derivatives of retinol (vitamin A) carrying a biotin group for use in the isolation and purification of Retinol Binding Proteins involved in the visual cycle. The first biotinylated retinoid was synthesized in 2002 [1] and was used in the isolation and characterization of RPE65.[2]
Notes and references
- ↑ Nesnas, N.; Rando, R. R.; Nakanishi, K. (2002). "Synthesis of biotinylated retinoids for cross-linking and isolation of retinol binding proteins". Tetrahedron 58 (32): 6577. doi:10.1016/S0040-4020(02)00667-1. http://www.columbia.edu/cu/chemistry/groups/nakanishi/publication/712-Synthesis%20of%20Biotinylated%20Retinoids%20for%20Cross-Linking%20and%20Isolation%20of%20Retinol%20Binding%20Proteins.pdf.
- ↑ Jahng, W. J.; David, C.; Nesnas, N.; Nakanishi, K.; Rando, R. R. (2003). "A Cleavable Affinity Biotinylating Agent Reveals a Retinoid Binding Role for RPE65†". Biochemistry 42 (20): 6159–6168. doi:10.1021/bi034002i. PMID 12755618.
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