Chemistry:DOTAM
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Short description: Organic compound used as a chelator
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| Names | |
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| IUPAC name
2-[4,7,10-tris(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide
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Other names
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C16H32N8O4 | |
| Molar mass | 400.484 g·mol−1 |
| Appearance | White powder |
| Soluble (hygroscopic) | |
| Hazards | |
| GHS pictograms | 
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| GHS Signal word | Warning |
| H315, H319, H335 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
DOTAM (also known as TCMC) is an organic compound used as a chelator much like its carboxylic acid analog DOTA. A derivative with a reactive linking group of para-isothiocyanatobenzyl attached to the cyclen ring is also of interest as a bifunctional chelator (BFC).[1][2]
References
- ↑ Brennecke, Benjamin; Wang, Qinghua; Haap, Wolfgang; Grether, Uwe; Hu, Hai-Yu; Nazaré, Marc (2021-04-21). "DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells" (in en). Bioconjugate Chemistry 32 (4): 702–712. doi:10.1021/acs.bioconjchem.0c00699. ISSN 1043-1802. PMID 33691062. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.0c00699.
- ↑ Stenberg, Vilde Yuli; Larsen, Roy Hartvig; Ma, Li-Wei; Peng, Qian; Juzenas, Petras; Bruland, Øyvind Sverre; Juzeniene, Asta (January 2021). "Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer" (in en). International Journal of Molecular Sciences 22 (9): 4815. doi:10.3390/ijms22094815. PMID 34062920.
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