Chemistry:Dextran sulphate sodium
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Dextran sulphate sodium (DSS), or dextran sodium sulphate (or any of the former with "sulfate") is a synthetic sulphated polysaccharide with anticoangulant activity used in immunological research to induce colitis.[1][2] Dextran polymer molecules with a molecular weight of 36–50 kDa are frequently used to this end.[2]
DSS-induced colitis
DSS-induced colitis is the most widely used mouse model of colitis, such as is seen in inflammatory bowel disease (IBD). Acute colitis can be achieved within 7-10 days, while chronic colitis can be induced by 3-5 cycles of the former with 1-2 weeks in between each cycle.[2]
Mechanism
DSS is thought to induce colitis by causing injury to the colonic epithelium. The sulphate groups make the dextran molecules highly negatively charged and induce erosions in the epithelium, eventually compromising its integrity and increasing its permeability, while DSS's anticoagulant action promotes intestinal bleeding.[2]
References
- ↑ Eichele, Derrick D; Kharbanda, Kusum K (2017-09-07). "Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis". World Journal of Gastroenterology 23 (33): 6016–6029. doi:10.3748/wjg.v23.i33.6016. ISSN 1007-9327. PMID 28970718.
- ↑ 2.0 2.1 2.2 2.3 Jamwal, Sumit; Kumar, Puneet (2017-01-01), Conn, P. Michael, ed., "Chapter 19 - Animal Models of Inflammatory Bowel Disease", Animal Models for the Study of Human Disease (Second Edition) (Academic Press): pp. 467–477, ISBN 978-0-12-809468-6, https://www.sciencedirect.com/science/article/pii/B978012809468600019X, retrieved 2023-12-25
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