Chemistry:Dysidenin
Dysidenin is an alkaloid toxin found in the marine sponge Lamellodysidea herbacea (previously known as Dysidea herbacea)[1] which has a lethal effect on certain fish species and other marine organisms. The toxic mechanism of dysidenin is linked to its ability to inhibit iodide transport in thyroid cells.[2] Dysidenin was originally isolated in 1977.[3]
There is a regional variation in the metabolites produced by L. herbacea, as evidenced by the isolation of dysidenin from organism samples obtained from the Great Barrier Reef, while it was absent in samples from the Caroline Islands.[4] This variation has been attributed to different strains of the cyanobacterium Hormoscilla spongeliae that are hosted by different morphological variations of the sponge.[5][6]
References
- ↑ "WoRMS - World Register of Marine Species - Dysidea herbacea (Keller, 1889)". https://www.marinespecies.org/aphia.php?p=taxdetails&id=220470.
- ↑ Van Sande, J; Deneubourg, F; Beauwens, R; Braekman, JC; Daloze, D; Dumont, JE (April 1990). "Inhibition of iodide transport in thyroid cells by dysidenin, a marine toxin, and some of its analogs.". Molecular Pharmacology 37 (4): 583–9. doi:10.1016/S0026-895X(25)10846-8. PMID 2157965.
- ↑ Kazlauskas, R.; Lidgard, R.O.; Wells, R.J.; Vetter, W. (January 1977). "A novel hexachloro-metabolite from the sponge dysidea herbacea". Tetrahedron Letters 18 (36): 3183–3186. doi:10.1016/S0040-4039(01)83192-0.
- ↑ Marine Natural Products: Chemical and Biological Perspectives.. 2. Oxford: Elsevier Science. 1978. p. 370. ISBN 9780323151863.
- ↑ Thacker, R. W.; Starnes, S. (April 2003). "Host specificity of the symbiotic cyanobacterium Oscillatoria spongeliae in marine sponges, Dysidea spp." (in en). Marine Biology 142 (4): 643–648. doi:10.1007/s00227-002-0971-x. ISSN 0025-3162. Bibcode: 2003MarBi.142..643T. http://link.springer.com/10.1007/s00227-002-0971-x.
- ↑ Ridley, Christian P.; Bergquist, Patricia R.; Harper, Mary Kay; Faulkner, D. John; Hooper, John N.A.; Haygood, Margo G. (March 2005). "Speciation and Biosynthetic Variation in Four Dictyoceratid Sponges and Their Cyanobacterial Symbiont, Oscillatoria spongeliae" (in en). Chemistry & Biology 12 (3): 397–406. doi:10.1016/j.chembiol.2005.02.003. PMID 15797223. https://linkinghub.elsevier.com/retrieve/pii/S1074552105000396.
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