Chemistry:Fazamorexant
Fazamorexant (INN), sold under the brand name Mengping, is an orexin receptor antagonist which is used in the treatment of insomnia in China.[1][2][3][4] It is taken orally.[1]
The drug acts as a dual orexin receptor antagonist (DORA), or as an antagonist of both the orexin OX1 and OX2 receptors.[3][4] Its time to peak levels is 0.6 to 1.3 hours and its elimination half-life is 1.9 to 3.7 hours.[5]
Fazamorexant was developed by Jiangsu Yangtze River Pharmaceutical Group and/or Shanghai Haiyan Pharmaceutical Technology in China.[1][2][3] Relatively little public information is available on fazamorexant.[3] This was such that it had to be excluded from a 2020 literature review of orexin receptor antagonists for insomnia.[3] The drug was approved in China in May 2026.[1][6]
See also
- Orexin receptor antagonist
- List of investigational insomnia drugs
- Vornorexant and seltorexant (other short-acting orexin antagonists)
References
- ↑ 1.0 1.1 1.2 1.3 "YZJ 1139". 14 September 2022. https://adisinsight.springer.com/drugs/800070010.
- ↑ 2.0 2.1 "Delving into the Latest Updates on Fazamorexant with Synapse". 31 October 2024. https://synapse.patsnap.com/drug/c7fe97b9b5a74ad29ac29df5588f38be.
- ↑ 3.0 3.1 3.2 3.3 3.4 "Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders". Expert Opinion on Drug Metabolism & Toxicology 16 (11): 1063–1078. November 2020. doi:10.1080/17425255.2020.1817380. PMID 32901578.
- ↑ 4.0 4.1 "Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation". Neuroscience and Biobehavioral Reviews 147. April 2023. doi:10.1016/j.neubiorev.2023.105107. PMID 36828161.
- ↑ "Pharmacokinetics, Pharmacodynamic, Safety and Tolerability of Fazamorexant, a Novel Dual Orexin Receptor Antagonist: Report of the First-in-Human Study". Drug Design, Development and Therapy 19: 5271–5282. 19 June 2025. doi:10.2147/DDDT.S501111. PMID 40552089.
- ↑ "国家药监局批准法赞雷生片上市" (in zh). 21 May 2026. https://www.nmpa.gov.cn/zhuanti/cxylqx/cxypxx/20260521165336134.html.
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