Chemistry:Forster–Decker method
From HandWiki
The Forster–Decker method is a series of chemical reactions that have the effect of mono-alkylating a primary amine (1), forming a secondary amine (6).[1][2] The process occurs by way of transient formation of an imine (3) that undergoes the actual alkylation reaction.
Process stages
- Conversion of the primary amine to an imine (Schiff base) using an aldehyde.[3]
- Alkylation of the imine using an alkyl halide, forming an iminium ion.[4]
- Hydrolysis of the iminium, releasing the secondary amine and regenerating the aldehyde. [5]
Because the actual alkylation occurs on the imine, over-alkylation is not possible. Therefore, this method does not suffer from side-reactions such as formation of tertiary amines as a simple SN2-type process can.
See also
References
- ↑ Forster, Martin Onslow (1899). "XCI.–Influence of substitution on specific rotation in the bornylamine series". Journal of the Chemical Society, Transactions 75: 934–935. doi:10.1039/CT8997500934. https://zenodo.org/record/1763692.
- ↑ Decker, H.; Becker, P. Ann. 1913, 395, 362.
- ↑ McMurry, John (1988). Organic Chemistry (Second ed.). Brooks/Cole Publishing Company. p. 674-675. ISBN 0-534-07968-7.
- ↑ "Forster-Decker Amine Synthesis". 2011–2022. https://synarchive.com/named-reactions/forster-decker-amine-synthesis.
- ↑ "Imine and Enamine Hydrolysis Mechanism". 2016–2022. https://www.chemistrysteps.com/imine-and-enamine-hydrolysis-mechanism/.
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