Chemistry:Ganfeborole

From HandWiki

Ganfeborole (GSK3036656, GSK-070) is an experimental antibiotic which shows activity against Mycobacterium tuberculosis. It acts as a potent and selective inhibitor of the bacterial leucyl-tRNA synthetase enzyme, and is currently in clinical trials.[1][2][3]

References

  1. ↑ "Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)". Journal of Medicinal Chemistry 60 (19): 8011–8026. October 2017. doi:10.1021/acs.jmedchem.7b00631. PMID 28953378. 
  2. ↑ "New antituberculous drugs derived from natural products: current perspectives and issues in antituberculous drug development". The Journal of Antibiotics 71: 15–25. November 2017. doi:10.1038/ja.2017.126. PMID 29089593. 
  3. ↑ "A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial". Nature Medicine 30 (3): 896–904. March 2024. doi:10.1038/s41591-024-02829-7. PMID 38365949. 



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