Chemistry:Glidant
A glidant is a substance that is added to a powder to improve its flowability. A glidant will only work at a certain range of concentrations. Above a certain concentration, the glidant will in fact function to inhibit flowability.
In tablet manufacture, glidants are usually added just prior to compression.
Examples
Examples of glidants include ascorbyl palmitate,[1] calcium palmitate,[2] magnesium stearate, fumed silica (colloidal silicon dioxide), starch and talc.[3]
Mechanism of action
A glidant's effect is due to the counter-action of factors that cause poor flowability of powders. For instance, correcting surface irregularity, reducing interparticular friction and decreasing surface charge. The result is a decrease in the angle of repose which is an indication of an enhanced powder's flowability.
References
- ↑ Kim, Dong Sup; Joo Hyun Baik & Hyun Mook Jung et al., "Use of ascorbyl palmitate and ascorbyl stearate as glidant for tablets", KR patent 101440100, published 2014-09-17, assigned to Cosmax Bio Co. Ltd.
- ↑ "Vitamin & Supplement Recommendations for Your Health Concerns - Swanson®". https://www.swansonvitamins.com/quality/additives-fillers.html.
- ↑ "SMI: Talc as a Glidant & Lubricant". 2012 Specialty Minerals Inc.. http://www.specialtyminerals.com/specialty-applications/specialty-markets-for-minerals/nutritional-supplements/talc-as-a-glidant-lubricant/. Retrieved 19 March 2014.
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